The landscape of new drugs in lymphoma
Identifieur interne : 001568 ( Main/Exploration ); précédent : 001567; suivant : 001569The landscape of new drugs in lymphoma
Auteurs : Anas Younes [États-Unis] ; Stephen Ansell [États-Unis] ; Nathan Fowler [États-Unis] ; Wyndham Wilson [États-Unis] ; Sven De Vos [États-Unis] ; John Seymour [Australie] ; Ranjana Advani [États-Unis] ; Andres Forero [États-Unis] ; Franck Morschhauser [France] ; Marie Jose Kersten [Pays-Bas] ; Kensei Tobinai [Japon] ; Pier Luigi Zinzani [Italie] ; Emanuele Zucca [Suisse] ; Jeremy Abramson [États-Unis] ; Julie Vose [États-Unis]Source :
- Nature reviews. Clinical oncology [ 1759-4774 ] ; 2016.
Descripteurs français
- KwdFr :
- Antinéoplasiques (usage thérapeutique), Découverte de médicament (), Découverte de médicament (tendances), Facteurs immunologiques (usage thérapeutique), Humains, Immunothérapie (), Lymphomes (traitement médicamenteux), Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Thérapie moléculaire ciblée (), Thérapie moléculaire ciblée (tendances).
- MESH :
- tendances : Découverte de médicament, Thérapie moléculaire ciblée.
- traitement médicamenteux : Lymphomes.
- usage thérapeutique : Antinéoplasiques, Facteurs immunologiques, Protocoles de polychimiothérapie antinéoplasique.
- Découverte de médicament, Humains, Immunothérapie, Thérapie moléculaire ciblée.
English descriptors
- KwdEn :
- Antineoplastic Agents (therapeutic use), Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Drug Discovery (methods), Drug Discovery (trends), Humans, Immunologic Factors (therapeutic use), Immunotherapy (methods), Lymphoma (drug therapy), Molecular Targeted Therapy (methods), Molecular Targeted Therapy (trends).
- MESH :
- chemical , therapeutic use : Antineoplastic Agents, Immunologic Factors.
- drug therapy : Lymphoma.
- methods : Drug Discovery, Immunotherapy, Molecular Targeted Therapy.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- trends : Drug Discovery, Molecular Targeted Therapy.
- Humans.
Abstract
The landscape of drugs for the treatment of lymphoma has become crowded in light of the plethora of new agents, necessitating the efficient prioritization of drugs for expedited development. The number of drugs available, and the fact that many can be given for an extended period of time, has resulted in the emergence of new challenges; these include determining the optimal duration of therapy, and the need to balance costs, benefits, and the risk of late-onset toxicities. Moreover, with the increase in the number of available investigational drugs, the number of possible combinations is becoming overwhelming, which necessitates prioritization plans for the selective development of novel combination regimens. In this Review, we describe the mospromising agents in clinical development for the treatment of lymphoma, and provide expert opinion on new strategies that might enable more streamlined drug development. We also address new approaches for patient selection and for incorporating new end points into clinical trials.
Url:
DOI: 10.1038/nrclinonc.2016.205
PubMed: 28031560
PubMed Central: 5611863
Affiliations:
- Australie, France, Italie, Japon, Pays-Bas, Suisse, États-Unis
- Hollande-Septentrionale, Maryland
- Amsterdam
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Lille</wicri:noRegion><wicri:noRegion>59037 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Kersten, Marie Jose" sort="Kersten, Marie Jose" uniqKey="Kersten M" first="Marie Jose" last="Kersten">Marie Jose Kersten</name><affiliation wicri:level="3"><nlm:aff id="A10">Department of Haematology, Academic Medical Center and LYMMCARE, Amsterdam, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Haematology, Academic Medical Center and LYMMCARE, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Tobinai, Kensei" sort="Tobinai, Kensei" uniqKey="Tobinai K" first="Kensei" last="Tobinai">Kensei Tobinai</name><affiliation wicri:level="1"><nlm:aff id="A11">Haematology Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104 0045, Japan</nlm:aff><country 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Center, 1275 York Avenue, New York, New York 10021</wicri:regionArea><wicri:noRegion>New York 10021</wicri:noRegion></affiliation></author><author><name sortKey="Ansell, Stephen" sort="Ansell, Stephen" uniqKey="Ansell S" first="Stephen" last="Ansell">Stephen Ansell</name><affiliation wicri:level="1"><nlm:aff id="A2">Division of Haematology, Mayo Clinic, 200 1st St Sw, Rochester, Minnesota 55905, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Haematology, Mayo Clinic, 200 1st St Sw, Rochester, Minnesota 55905</wicri:regionArea><wicri:noRegion>Minnesota 55905</wicri:noRegion></affiliation></author><author><name sortKey="Fowler, Nathan" sort="Fowler, Nathan" uniqKey="Fowler N" first="Nathan" last="Fowler">Nathan Fowler</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Lymphoma and Myeloma, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Lymphoma and Myeloma, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, Wyndham" sort="Wilson, Wyndham" uniqKey="Wilson W" first="Wyndham" last="Wilson">Wyndham Wilson</name><affiliation wicri:level="2"><nlm:aff id="A4">Lymphoid Malignancies Branch, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lymphoid Malignancies Branch, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="De Vos, Sven" sort="De Vos, Sven" uniqKey="De Vos S" first="Sven" last="De Vos">Sven De Vos</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Medicine, Ronald Reagan UCLA Medical Center, Santa Monica, California 90404, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Ronald Reagan UCLA Medical Center, Santa Monica, California 90404</wicri:regionArea><wicri:noRegion>California 90404</wicri:noRegion></affiliation></author><author><name sortKey="Seymour, John" sort="Seymour, John" uniqKey="Seymour J" first="John" last="Seymour">John Seymour</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Haematology, Peter MacCallum Cancer Centre, A’Beckett Street, East Melbourne, Victoria 8006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Haematology, Peter MacCallum Cancer Centre, A’Beckett Street, East Melbourne, Victoria 8006</wicri:regionArea><wicri:noRegion>Victoria 8006</wicri:noRegion></affiliation></author><author><name sortKey="Advani, Ranjana" sort="Advani, Ranjana" uniqKey="Advani R" first="Ranjana" last="Advani">Ranjana Advani</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Oncology, Stanford University Cancer Center, 875 Blake Wilbur Drive, Stanford, California 94305, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Oncology, Stanford University Cancer Center, 875 Blake Wilbur Drive, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation></author><author><name sortKey="Forero, Andres" sort="Forero, Andres" uniqKey="Forero A" first="Andres" last="Forero">Andres Forero</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Haematology and Oncology, University of Alabama School of Medicine, 1720 2nd Avenue South, NP2540, Birmingham, Alabama 35294 3300, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Haematology and Oncology, University of Alabama School of Medicine, 1720 2nd Avenue South, NP2540, Birmingham, Alabama 35294 3300</wicri:regionArea><wicri:noRegion>Alabama 35294 3300</wicri:noRegion></affiliation></author><author><name sortKey="Morschhauser, Franck" sort="Morschhauser, Franck" uniqKey="Morschhauser F" first="Franck" last="Morschhauser">Franck Morschhauser</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Haematology, Hopital Claude Huriez, F-59037 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Haematology, Hopital Claude Huriez, F-59037 Lille</wicri:regionArea><wicri:noRegion>59037 Lille</wicri:noRegion><wicri:noRegion>59037 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Kersten, Marie Jose" sort="Kersten, Marie Jose" uniqKey="Kersten M" first="Marie Jose" last="Kersten">Marie Jose Kersten</name><affiliation wicri:level="3"><nlm:aff id="A10">Department of Haematology, Academic Medical Center and LYMMCARE, Amsterdam, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Haematology, Academic Medical Center and LYMMCARE, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Tobinai, Kensei" sort="Tobinai, Kensei" uniqKey="Tobinai K" first="Kensei" last="Tobinai">Kensei Tobinai</name><affiliation wicri:level="1"><nlm:aff id="A11">Haematology Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104 0045, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Haematology Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104 0045</wicri:regionArea><wicri:noRegion>Tokyo 104 0045</wicri:noRegion></affiliation></author><author><name sortKey="Zinzani, Pier Luigi" sort="Zinzani, Pier Luigi" uniqKey="Zinzani P" first="Pier Luigi" last="Zinzani">Pier Luigi Zinzani</name><affiliation wicri:level="1"><nlm:aff id="A12">Institute of Haematology “L. e A. Seragnoli,” University of Bologna, Via Massarenti, 9 40138 Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Haematology “L. e A. Seragnoli,” University of Bologna, Via Massarenti, 9 40138 Bologna</wicri:regionArea><wicri:noRegion>9 40138 Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Zucca, Emanuele" sort="Zucca, Emanuele" uniqKey="Zucca E" first="Emanuele" last="Zucca">Emanuele Zucca</name><affiliation wicri:level="1"><nlm:aff id="A13">Oncology Institute of Southern Switzerland, Ospedale San Giovanni, 6500 Bellinzona, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Oncology Institute of Southern Switzerland, Ospedale San Giovanni, 6500 Bellinzona</wicri:regionArea><wicri:noRegion>6500 Bellinzona</wicri:noRegion></affiliation></author><author><name sortKey="Abramson, Jeremy" sort="Abramson, Jeremy" uniqKey="Abramson J" first="Jeremy" last="Abramson">Jeremy Abramson</name><affiliation wicri:level="1"><nlm:aff id="A14">Massachusetts General Hospital Cancer Center, Yawkey Center for Outpatient Care, Mailstop: Yawkey 9A, 32 Fruit Street, Boston, Massachusetts 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital Cancer Center, Yawkey Center for Outpatient Care, Mailstop: Yawkey 9A, 32 Fruit Street, Boston, Massachusetts 02114</wicri:regionArea><wicri:noRegion>Massachusetts 02114</wicri:noRegion></affiliation></author><author><name sortKey="Vose, Julie" sort="Vose, Julie" uniqKey="Vose J" first="Julie" last="Vose">Julie Vose</name><affiliation wicri:level="1"><nlm:aff id="A15">UNMC Oncology/Haematology Division, 987680 Nebraska Medical Center, Omaha, Nebraska 681980 7680, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>UNMC Oncology/Haematology Division, 987680 Nebraska Medical Center, Omaha, Nebraska 681980 7680</wicri:regionArea><wicri:noRegion>Nebraska 681980 7680</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature reviews. Clinical oncology</title><idno type="ISSN">1759-4774</idno><idno type="eISSN">1759-4782</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic Agents (therapeutic use)</term><term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term><term>Drug Discovery (methods)</term><term>Drug Discovery (trends)</term><term>Humans</term><term>Immunologic Factors (therapeutic use)</term><term>Immunotherapy (methods)</term><term>Lymphoma (drug therapy)</term><term>Molecular Targeted Therapy (methods)</term><term>Molecular Targeted Therapy (trends)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antinéoplasiques (usage thérapeutique)</term><term>Découverte de médicament ()</term><term>Découverte de médicament (tendances)</term><term>Facteurs immunologiques (usage thérapeutique)</term><term>Humains</term><term>Immunothérapie ()</term><term>Lymphomes (traitement médicamenteux)</term><term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term><term>Thérapie moléculaire ciblée ()</term><term>Thérapie moléculaire ciblée (tendances)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Agents</term><term>Immunologic Factors</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphoma</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Discovery</term><term>Immunotherapy</term><term>Molecular Targeted Therapy</term></keywords><keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Découverte de médicament</term><term>Thérapie moléculaire ciblée</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Lymphomes</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Drug Discovery</term><term>Molecular Targeted Therapy</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antinéoplasiques</term><term>Facteurs immunologiques</term><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Découverte de médicament</term><term>Humains</term><term>Immunothérapie</term><term>Thérapie moléculaire ciblée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The landscape of drugs for the treatment of lymphoma has become crowded in light of the plethora of new agents, necessitating the efficient prioritization of drugs for expedited development. The number of drugs available, and the fact that many can be given for an extended period of time, has resulted in the emergence of new challenges; these include determining the optimal duration of therapy, and the need to balance costs, benefits, and the risk of late-onset toxicities. Moreover, with the increase in the number of available investigational drugs, the number of possible combinations is becoming overwhelming, which necessitates prioritization plans for the selective development of novel combination regimens. In this Review, we describe the mospromising agents in clinical development for the treatment of lymphoma, and provide expert opinion on new strategies that might enable more streamlined drug development. We also address new approaches for patient selection and for incorporating new end points into clinical trials.</p></div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Italie</li><li>Japon</li><li>Pays-Bas</li><li>Suisse</li><li>États-Unis</li></country><region><li>Hollande-Septentrionale</li><li>Maryland</li></region><settlement><li>Amsterdam</li></settlement></list><tree><country name="États-Unis"><noRegion><name sortKey="Younes, Anas" sort="Younes, Anas" uniqKey="Younes A" first="Anas" last="Younes">Anas Younes</name></noRegion><name sortKey="Abramson, Jeremy" sort="Abramson, Jeremy" uniqKey="Abramson J" first="Jeremy" last="Abramson">Jeremy Abramson</name><name sortKey="Advani, Ranjana" sort="Advani, Ranjana" uniqKey="Advani R" first="Ranjana" last="Advani">Ranjana Advani</name><name sortKey="Ansell, Stephen" sort="Ansell, Stephen" uniqKey="Ansell S" first="Stephen" last="Ansell">Stephen Ansell</name><name sortKey="De Vos, Sven" sort="De Vos, Sven" uniqKey="De Vos S" first="Sven" last="De Vos">Sven De Vos</name><name sortKey="Forero, Andres" sort="Forero, Andres" uniqKey="Forero A" first="Andres" last="Forero">Andres Forero</name><name sortKey="Fowler, Nathan" sort="Fowler, Nathan" uniqKey="Fowler N" first="Nathan" last="Fowler">Nathan Fowler</name><name sortKey="Vose, Julie" sort="Vose, Julie" uniqKey="Vose J" first="Julie" last="Vose">Julie Vose</name><name sortKey="Wilson, Wyndham" sort="Wilson, Wyndham" uniqKey="Wilson W" first="Wyndham" last="Wilson">Wyndham Wilson</name></country><country name="Australie"><noRegion><name sortKey="Seymour, John" sort="Seymour, John" uniqKey="Seymour J" first="John" last="Seymour">John Seymour</name></noRegion></country><country name="France"><noRegion><name sortKey="Morschhauser, Franck" sort="Morschhauser, Franck" uniqKey="Morschhauser F" first="Franck" last="Morschhauser">Franck Morschhauser</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Kersten, Marie Jose" sort="Kersten, Marie Jose" uniqKey="Kersten M" first="Marie Jose" last="Kersten">Marie Jose Kersten</name></region></country><country name="Japon"><noRegion><name sortKey="Tobinai, Kensei" sort="Tobinai, Kensei" uniqKey="Tobinai K" first="Kensei" last="Tobinai">Kensei Tobinai</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Zinzani, Pier Luigi" sort="Zinzani, Pier Luigi" uniqKey="Zinzani P" first="Pier Luigi" last="Zinzani">Pier Luigi Zinzani</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Zucca, Emanuele" sort="Zucca, Emanuele" uniqKey="Zucca E" first="Emanuele" last="Zucca">Emanuele Zucca</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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